And yes, roe as in fish eggs. While traditional PDRN often comes from salmon DNA, today’s clean beauty innovators are swapping fish for fermented grains and botanicals.
Collagen’s role as the structural support system of the skin maintaining elasticity, texture, and moisture is undeniable. But a trending K‑Beauty ingredient, Polydeoxyribonucleotide (PDRN), has been capturing attention for its repair and barrier-strengthening benefits.
Clarifying “Salmon” and Delivery Confusion
A few important details often get mixed up when people talk about PDRN. Firstly, when sources say “salmon,” they more often than not mean salmon trout (Oncorhynchus mykiss, also known as rainbow trout) or chum salmon (Oncorhynchus keta) sperm DNA, which are the common sources in clinical use.
Secondly, PDRN molecules are quite large, therefore PDRN applied topically often can’t penetrate deeply through the skin’s barrier to reach the dermis, where true cellular regeneration occurs. That’s why injectable PDRN treatments are widely used in dermatology. They bypass the skin barrier entirely. When used in topical serums or creams (including vegan versions), PDRN may still offer surface-level benefits like hydration, calming, and barrier support, but won’t deliver the same regenerative effects as injectable forms unless paired with penetration-enhancing technologies like microneedling.
Enter c-PDRN®
c-PDRN® (Cosmetic Polydeoxyribonucleotide) is a patented, proprietary form of PDRN developed by Rejuran, a leading K-beauty brand specializing in salmon DNA-based skincare.
c-PDRN® is specifically optimized for topical cosmetic applications through Rejuran’s proprietary DNA Optimizing Technology (DOT™), which refines the molecule for better stability, absorption, and performance. So for those unable to fly to South Korea—or simply seeking a less-invasive alternative—c-PDRN® offers a science-backed way to experience the regenerative benefits of PDRN at home.
Beauty Editor’s Note
While salmon sperm injections are trending for their regenerative skin benefits, they’re reportedly quite painful — so only the truly committed (and curious) beauty editors have taken the plunge. For example, beauty journalist Sarah Y. Wu documented her firsthand experience for Marie Claire — and yes, she confirms it’s not for the faint of heart.
Is it Farmed or Wild Salmon?
The salmon used for PDRN extraction is primarily farmed rather than wild-caught, as farming ensures consistent supply, controlled quality, and lower risk of contaminants (pollutants). Some premium brands do however claim to use wild salmon for “purer” DNA, though this is less common and harder to verify.
Are Salmon-Based Treatments Safe?
While salmon DNA skincare may offer regenerative benefits, it’s not without risks. Allergic reactions are possible, particularly for those with sensitivities to fish or shellfish. And because salmon facials are relatively new in the beauty world, their long-term safety and effectiveness are not yet fully established. Always consult a professional if you’re unsure
Where Vegan PDRN Comes From
Purple Rice–Derived PDRN
Another innovative source is purple rice, a pigmented grain rich in anthocyanins and antioxidants. Brands like Eqqual Berry are incorporating what they call “Rice PDRN” into serums formulated to refine skin texture, minimize the appearance of pores, and support elasticity and hydration. Developed through advanced plant cell culture methods, this rice-derived PDRN offers a sustainable, vegan-friendly alternative to traditional DNA-based ingredients—delivering visible results without compromising clean beauty principles.
Ginseng-Derived PDRN
In recent studies, Panax ginseng has shown promising potential as a vegan source of PDRN. Using advanced technology, researchers have successfully extracted purified polydeoxyribonucleotides from ginseng root cells, offering regenerative benefits without animal DNA. Ginseng-derived PDRN is now being used in vegan serums to support wound healing, strengthen the skin barrier, and improve visible signs of aging.
How Vegan PDRN Benefits Your Skin
- Stimulates cellular turnover and collagen production
- Enhances barrier repair, soothing sensitivity
- Improves hydration, texture, and glow—without animal sourcing
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Vegan PDRN Innovations in Clean Skincare
Eqqual Berry Purple PDRN Serum
This vegan serum features Rice PDRN, derived from antioxidant-rich purple rice, to help refine skin texture, reduce the appearance of pores, and support post-acne recovery. A Korean clean beauty innovation that’s cruelty-free, sustainable, and powered by plant biotechnology.
VT Cosmetics PDRN 100 Essence
With 100,000ppm of ginseng-derived vegan PDRN, this glow-boosting essence helps promote collagen production, barrier repair, and long-lasting hydration—without using animal DNA. A science-first solution for skin resilience, straight from Korea’s leading biotech labs.
ANUA PDRN Deep Hydrating Essential Set
A luxury clean beauty set from ANUA featuring vegan PDRN to deeply hydrate, repair, and strengthen the skin barrier. This essential kit delivers science-backed anti-aging benefits without compromise.
Fragrance status: 100% fragrance-free — gentle enough for sensitive skin.
