Ingredient-Led Brief

Clean Beauty Alternatives to NAD+ Injections

NAD+ injections and IV drips have been gaining popularity in wellness circles for their supposed anti-aging, energizing, and detoxifying benefits. Influencers and biohackers alike swear by them to boost everything from skin glow to brain power.

But what if you’re not into needles — or the steep price tag that comes with them? Not to worry, you don’t have to book into a medical spa to get the skin benefits of NAD+. With the right topical ingredients, you can support your skin’s natural repair, hydration, and glow, without an IV drip in sight!

What is NAD+ and Why Does Your Skin Love it?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It fuels cellular repair, collagen production, and DNA protection–all of which decline as we age. While NAD+ itself is too large and unstable to penetrate the skin, its precursors–especially niacinamide (vitamin B3)–are effective when applied topically.

Niacinamide: The Topical NAD+ Alternative

Niacinamide helps your skin:

  • Boost ceramide production for better hydration
  • Brighten dull or uneven skin tone
  • Calm redness and inflammation
  • Minimize pores and fine lines
  • Fight oxidative stress


It’s one of the most studied, gentle, and effective ingredients in clean beauty, making it a must-have if you’re chasing that post-IV glow, minus the needles.

Clean Beauty Products with Niacinamide (No Needles Required)

Here are a few clean, vegan & cruelty-free non-toxic skincare products that deliver NAD+ support through niacinamide:

Clean Beauty Products with Niacinamide (No Needles Required)

Editor’s Pick

PURITO Galacto Niacin 97 Power Essence

This clean, niacinamide-powered essence helps boost hydration, brighten skin tone, and calm irritation—no needles required. A great choice if you want NAD+ benefits without the IV drip.

Editor’s Pick

NATURIUM Niacinamide Face Serum

Formulated with 12% niacinamide, this serum supports clear, even-toned skin while minimizing the appearance of pores and fine lines. Naturium is known for clean, science-backed skincare at an accessible price.

Editor’s Pick

Youth To The People Superfood Skin Drip Face Serum

This nutrient-rich serum blends niacinamide with kale, spinach, and green tea to hydrate, brighten, and revitalize tired skin. A luxe clean-beauty pick with a cult following.

Editor’s Pick

Merit Beauty Great Skin Instant Glow Serum

This lightweight, bi-phase serum hydrates and plumps the skin with niacinamide and hyaluronic acid. Merit is vegan, cruelty-free, and designed for minimalist, clean beauty routines.




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